Kv1.3 plays an essential role in the immune response mediated by leukocytes and is functional at both the plasma membrane and the inner mitochondrial membrane. This channel may be present in mitochondria ( Parrasia et al. Frag(304-613)) to form a functional channel independently of the S1-S2 linkage ( Lamothe et al. The N-terminus and S1 of Kv1.5 can attract and coassemble with the rest of the channel (i.e. Loss of function causes atrial fibrillation, a rhythm disorder characterized by chaotic electrical activity of cardiac atria ( Olson et al. This channel is regulation by sterols ( Balajthy et al. The microRNA, mmumiR449a, reduced the mRNA expression levels of transient receptor potential cation channel subfamily A member 1 (TRPA1), and calcium activated potassium channel subunit alpha1 (KCNMA1) and increased the level of transmembrane phosphatase with tension homology (TPTE) in the DRG cells ( Lu et al. During insertion of Kv1.3, the extended N-terminus of the second α-helix, S2, inside the ribosomal tunnel is converted into a helix in a transition that depends on the nascent peptide sequence at specific tunnel locations ( Tu and Deutsch 2017). Addtionally, Na vBeta1 interacts with the voltage sensing domain (VSD) of K v1.3 through W172 in the transmembrane segment to modify the gating process ( Kubota et al. Direct binding of caveolin regulates K v1 channels and allows association with lipid rafts ( Pérez-Verdaguer et al. Intracellular trafficking of the K V1.3 K + channel is regulated by the pro-domain of a matrix metalloprotease ( Nguyen et al. ![]() Interactions between the C-terminus of K v1.5 and K vβ regulate pyridine nucleotide-dependent changes in channel gating ( Tipparaju et al., 2012). The K v1.3 mitochondrial potassium channel is involved in apoptotic signalling in lymphocytes ( Gulbins et al., 2010). However, the heteromers have different biophysical and pharmacological properties. ![]() K v1.3 associates with the sequence similar (>80%) K v1.5 protein in macrophage forming heteromers that like K v1.3 homomers are r-margatoxin sensitive ( Vicente et al., 2006). Margatoxin-sensitive voltage-gated K + channel, Kv1.3 (in plasma and mitochondrial membranes of T lymphocytes) (Szabò et al., 2005).
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